Notable Human Exploration Space Disasters - Challenger
•The challenger disaster was another case of NASA’s over confidence and impatience in their Shuttle program. •The SRB engineers had warned their management they could not guarantee proper O-Ring sealing in these extreme cold temperatures. This was later overturned by SRB management and NASA was given a go to launch anyways. Pad Temperature was 29 °F and was 18°F overnight.
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http://images.nationalgeographic.com/wpf/media-live/photos/000/317/cache/challenger-disaster-myths-explosion_31734_600x450.jpg Challenger space shuttle disaster picture: Icicles hang from Challenger's launch tower the morning of the disaster. http://upload.wikimedia.org/wikipedia/commons/4/42/STS-51-L_grey_smoke_on_SRB.jpg
Solid Rocket Motor
The root cause of the disaster was when a O-Ring that was located at a connecting joint to the main external fuel tank (the large orange tank the shuttle is attached to, burned through to the outside of the SRB casing, burning a hole directly into the External Tank and when this hole created a structural failure of the tank at great aerodynamic stress during the launch phase, it basically caused the tank to crush inwards and release the oxidizer and fuel inside. When this large of amount of flammable mixture then reached the ignition source of the burning rocket engines, it exploded.

All 7 crew members died during the disaster.
The Shuttle did not explode itself, rather it broke up due to aerodynamic instability when srb’s seperated.
Crew was believed to be alive, but unconscious when crew cabin impacted water at over 200mph.
Crew was unconscious due to sudden loss of cabin pressure at high altitude, like when the oxygen masks deploy on airliners, for that very reason.